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According to the passage, ____ could be a factor in the development of Alzheimer's disease.

A a genetic risk factor
Although the possible causes of Alzheimer's disease is not the subject of this passage, a "genetic risk factor" is mentioned at the end of the first sentence. Therefore, you can infer that a genetic factor is a "risk" or possible cause. The longevity gene, KLOTHO, is not discussed as a cause of the disease, but merely a related subject.
B sex
C the KLOTHO gene
D a longevity gene